Genetic stability of live attenuated vaccines against potentially pandemic influenza viruses.
Identifieur interne : 000563 ( Main/Exploration ); précédent : 000562; suivant : 000564Genetic stability of live attenuated vaccines against potentially pandemic influenza viruses.
Auteurs : Irina Kiseleva [Russie] ; Irina Dubrovina [Russie] ; Ekaterina Fedorova [Russie] ; Natalie Larionova [Russie] ; Irina Isakova-Sivak [Russie] ; Ekaterina Bazhenova [Russie] ; Maria Pisareva [Russie] ; Victoria Kuznetsova [Russie] ; Jorge Flores [États-Unis] ; Larisa Rudenko [Russie]Source :
- Vaccine [ 1873-2518 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de mutations d'ADN, Animaux, Excrétion virale, Femelle, Glycoprotéine hémagglutinine du virus influenza (génétique), Grippe humaine (), Génome viral, Humains, Instabilité du génome, Jeune adulte, Mâle, Méthode en double aveugle, Ovule, Poulets, Réplication virale, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (isolement et purification), Sous-type H5N2 du virus de la grippe A (génétique), Sous-type H5N2 du virus de la grippe A (isolement et purification), Sous-type H7N3 du virus de la grippe A (génétique), Sous-type H7N3 du virus de la grippe A (isolement et purification), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (immunologie), Virus recombinants (génétique), Virus recombinants (isolement et purification).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H2N2 du virus de la grippe A, Sous-type H5N2 du virus de la grippe A, Sous-type H7N3 du virus de la grippe A, Virus recombinants.
- immunologie : Vaccins antigrippaux, Vaccins atténués.
- isolement et purification : Sous-type H2N2 du virus de la grippe A, Sous-type H5N2 du virus de la grippe A, Sous-type H7N3 du virus de la grippe A, Virus recombinants.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de mutations d'ADN, Animaux, Excrétion virale, Femelle, Grippe humaine, Génome viral, Humains, Instabilité du génome, Jeune adulte, Mâle, Méthode en double aveugle, Ovule, Poulets, Réplication virale.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Chickens, DNA Mutational Analysis, Double-Blind Method, Female, Genome, Viral, Genomic Instability, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (isolation & purification), Influenza A Virus, H5N2 Subtype (genetics), Influenza A Virus, H5N2 Subtype (isolation & purification), Influenza A Virus, H7N3 Subtype (genetics), Influenza A Virus, H7N3 Subtype (isolation & purification), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Male, Middle Aged, Ovum, Reassortant Viruses (genetics), Reassortant Viruses (isolation & purification), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (immunology), Virus Replication, Virus Shedding, Young Adult.
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N2 Subtype, Influenza A Virus, H7N3 Subtype, Reassortant Viruses.
- chemical , immunology : Influenza Vaccines, Vaccines, Attenuated.
- isolation & purification : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N2 Subtype, Influenza A Virus, H7N3 Subtype, Reassortant Viruses.
- prevention & control : Influenza, Human.
- Adolescent, Adult, Animals, Chickens, DNA Mutational Analysis, Double-Blind Method, Female, Genome, Viral, Genomic Instability, Humans, Male, Middle Aged, Ovum, Virus Replication, Virus Shedding, Young Adult.
Abstract
Ensuring genetic stability is a prerequisite for live attenuated influenza vaccine (LAIV). This study describes the results of virus shedding and clinical isolates' testing of Phase I clinical trials of Russian LAIVs against potentially pandemic influenza viruses in healthy adults.
DOI: 10.1016/j.vaccine.2015.09.050
PubMed: 26432909
Affiliations:
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Le document en format XML
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Pavlov Street , St Petersburg 197376, Russia. Electronic address: irina.v.kiseleva@mail.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376</wicri:regionArea><wicri:noRegion>St Petersburg 197376</wicri:noRegion></affiliation></author><author><name sortKey="Dubrovina, Irina" sort="Dubrovina, Irina" uniqKey="Dubrovina I" first="Irina" last="Dubrovina">Irina Dubrovina</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376</wicri:regionArea><wicri:noRegion>St Petersburg 197376</wicri:noRegion></affiliation></author><author><name sortKey="Fedorova, Ekaterina" sort="Fedorova, Ekaterina" uniqKey="Fedorova E" first="Ekaterina" last="Fedorova">Ekaterina Fedorova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376</wicri:regionArea><wicri:noRegion>St Petersburg 197376</wicri:noRegion></affiliation></author><author><name sortKey="Larionova, Natalie" sort="Larionova, Natalie" uniqKey="Larionova N" first="Natalie" last="Larionova">Natalie Larionova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376</wicri:regionArea><wicri:noRegion>St Petersburg 197376</wicri:noRegion></affiliation></author><author><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376</wicri:regionArea><wicri:noRegion>St Petersburg 197376</wicri:noRegion></affiliation></author><author><name sortKey="Bazhenova, Ekaterina" sort="Bazhenova, Ekaterina" uniqKey="Bazhenova E" first="Ekaterina" last="Bazhenova">Ekaterina Bazhenova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376</wicri:regionArea><wicri:noRegion>St Petersburg 197376</wicri:noRegion></affiliation></author><author><name sortKey="Pisareva, Maria" sort="Pisareva, Maria" uniqKey="Pisareva M" first="Maria" last="Pisareva">Maria Pisareva</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Virology, Institute of Influenza, St Petersburg 197376, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Molecular Virology, Institute of Influenza, St Petersburg 197376</wicri:regionArea><wicri:noRegion>St Petersburg 197376</wicri:noRegion></affiliation></author><author><name sortKey="Kuznetsova, Victoria" sort="Kuznetsova, Victoria" uniqKey="Kuznetsova V" first="Victoria" last="Kuznetsova">Victoria Kuznetsova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376</wicri:regionArea><wicri:noRegion>St Petersburg 197376</wicri:noRegion></affiliation></author><author><name sortKey="Flores, Jorge" sort="Flores, Jorge" uniqKey="Flores J" first="Jorge" last="Flores">Jorge Flores</name><affiliation wicri:level="1"><nlm:affiliation>PATH, Seattle, Washington, 98121, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>PATH, Seattle, Washington, 98121</wicri:regionArea><wicri:noRegion>98121</wicri:noRegion></affiliation></author><author><name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street , St Petersburg 197376, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Virology, Institute of Experimental Medicine, 12 Acad. 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(genetics)</term><term>Influenza A Virus, H7N3 Subtype (isolation & purification)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Male</term><term>Middle Aged</term><term>Ovum</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (isolation & purification)</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (immunology)</term><term>Virus Replication</term><term>Virus Shedding</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de mutations d'ADN</term><term>Animaux</term><term>Excrétion virale</term><term>Femelle</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Grippe humaine ()</term><term>Génome viral</term><term>Humains</term><term>Instabilité du génome</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Ovule</term><term>Poulets</term><term>Réplication virale</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (isolement et purification)</term><term>Sous-type H5N2 du virus de la grippe A (génétique)</term><term>Sous-type H5N2 du virus de la grippe A (isolement et purification)</term><term>Sous-type H7N3 du virus de la grippe A (génétique)</term><term>Sous-type H7N3 du virus de la grippe A (isolement et purification)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (administration et posologie)</term><term>Vaccins atténués (immunologie)</term><term>Virus recombinants (génétique)</term><term>Virus recombinants (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H5N2 Subtype</term><term>Influenza A Virus, H7N3 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H5N2 du virus de la grippe A</term><term>Sous-type H7N3 du virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H5N2 Subtype</term><term>Influenza A Virus, H7N3 Subtype</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H5N2 du virus de la grippe A</term><term>Sous-type H7N3 du virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Chickens</term><term>DNA Mutational Analysis</term><term>Double-Blind Method</term><term>Female</term><term>Genome, Viral</term><term>Genomic Instability</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Ovum</term><term>Virus Replication</term><term>Virus Shedding</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de mutations d'ADN</term><term>Animaux</term><term>Excrétion virale</term><term>Femelle</term><term>Grippe humaine</term><term>Génome viral</term><term>Humains</term><term>Instabilité du génome</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Ovule</term><term>Poulets</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ensuring genetic stability is a prerequisite for live attenuated influenza vaccine (LAIV). This study describes the results of virus shedding and clinical isolates' testing of Phase I clinical trials of Russian LAIVs against potentially pandemic influenza viruses in healthy adults.</div></front></TEI><affiliations><list><country><li>Russie</li><li>États-Unis</li></country></list><tree><country name="Russie"><noRegion><name sortKey="Kiseleva, Irina" sort="Kiseleva, Irina" uniqKey="Kiseleva I" first="Irina" last="Kiseleva">Irina Kiseleva</name></noRegion><name sortKey="Bazhenova, Ekaterina" sort="Bazhenova, Ekaterina" uniqKey="Bazhenova E" first="Ekaterina" last="Bazhenova">Ekaterina Bazhenova</name><name sortKey="Dubrovina, Irina" sort="Dubrovina, Irina" uniqKey="Dubrovina I" first="Irina" last="Dubrovina">Irina Dubrovina</name><name sortKey="Fedorova, Ekaterina" sort="Fedorova, Ekaterina" uniqKey="Fedorova E" first="Ekaterina" last="Fedorova">Ekaterina Fedorova</name><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name><name sortKey="Kuznetsova, Victoria" sort="Kuznetsova, Victoria" uniqKey="Kuznetsova V" first="Victoria" last="Kuznetsova">Victoria Kuznetsova</name><name sortKey="Larionova, Natalie" sort="Larionova, Natalie" uniqKey="Larionova N" first="Natalie" last="Larionova">Natalie Larionova</name><name sortKey="Pisareva, Maria" sort="Pisareva, Maria" uniqKey="Pisareva M" first="Maria" last="Pisareva">Maria Pisareva</name><name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name></country><country name="États-Unis"><noRegion><name sortKey="Flores, Jorge" sort="Flores, Jorge" uniqKey="Flores J" first="Jorge" last="Flores">Jorge Flores</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |